Memorial University DAI: Novel biodegradable and biocompatible elastomers for endostatin delivery

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Document Description

Title	Novel biodegradable and biocompatible elastomers for endostatin delivery
Author	Ellaboudy, Hany, 1969-
Description	Thesis (M.Sc.)--Memorial University of Newfoundland, 2008. Pharmacy
Date	2008
Pagination	xi, 128 leaves : ill. (some col.).
Subject	Elastomers--Therapeutic use; Neovascularization inhibitors; Polymeric drug delivery systems; Tumors--Treatment
Degree	M.Sc.
Degree Grantor	Memorial University of Newfoundland. School of Pharmacy
Discipline	Pharmacy
Language	Eng
Notes	Includes bibliographical references.
Abstract	Long term, localized continuous release of Endostatin (END) in the vicinity of tumour bed represents a new strategy for neoplastic treatment. The main reason of localization is to maximize the therapeutic outcome and at the same time to reduce the toxic effects on the surrounding tissues due to the exposure to the angiogenesis inhibitory effect of END. The main objective of this study was to design and formulate a biodegradable and biocompatible polymeric device for delivering END at a sustained and constant rate, and at a concentration within its therapeutic window by utilizing the osmotic release mechanism. The new device was prepared by mixing of END with osmotically active excipients and incorporate the mixture as solid particles within a rubbery polyermic matrix. The results demonstrated that this new device achieved a constant and sustained release rate for END for a certain period.
Type	Text
Resource Type	Electronic thesis or dissertation
Format	Image/jpeg; Application/pdf
Source	Paper copy kept in the Centre for Newfoundland Studies, Memorial University Libraries
Local Identifier	a2766209
Rights	The author retains copyright ownership and moral rights in this thesis. Neither the thesis nor substantial extracts from it may be printed or otherwise reproduced without the author's permission.
Collection	Electronic Theses and Dissertations
Scanning Status	Completed
PDF File	(4.87 MB) -- http://collections.mun.ca/PDFs/theses/Ellaboudy_Hany.pdf
CONTENTdm file name	10329.cpd