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Memorial University - Electronic Theses and Dissertations 5
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Document Description
TitleNovel biodegradable and biocompatible elastomers for endostatin delivery
AuthorEllaboudy, Hany, 1969-
DescriptionThesis (M.Sc.)--Memorial University of Newfoundland, 2008. Pharmacy
Paginationxi, 128 leaves : ill. (some col.).
SubjectElastomers--Therapeutic use; Neovascularization inhibitors; Polymeric drug delivery systems; Tumors--Treatment
Degree GrantorMemorial University of Newfoundland. School of Pharmacy
NotesIncludes bibliographical references.
AbstractLong term, localized continuous release of Endostatin (END) in the vicinity of tumour bed represents a new strategy for neoplastic treatment. The main reason of localization is to maximize the therapeutic outcome and at the same time to reduce the toxic effects on the surrounding tissues due to the exposure to the angiogenesis inhibitory effect of END. The main objective of this study was to design and formulate a biodegradable and biocompatible polymeric device for delivering END at a sustained and constant rate, and at a concentration within its therapeutic window by utilizing the osmotic release mechanism. The new device was prepared by mixing of END with osmotically active excipients and incorporate the mixture as solid particles within a rubbery polyermic matrix. The results demonstrated that this new device achieved a constant and sustained release rate for END for a certain period.
Resource TypeElectronic thesis or dissertation
FormatImage/jpeg; Application/pdf
SourcePaper copy kept in the Centre for Newfoundland Studies, Memorial University Libraries
Local Identifiera2766209
RightsThe author retains copyright ownership and moral rights in this thesis. Neither the thesis nor substantial extracts from it may be printed or otherwise reproduced without the author's permission.
CollectionElectronic Theses and Dissertations
Scanning StatusCompleted
PDF File(4.87 MB) --
CONTENTdm file name10329.cpd