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Memorial University - Electronic Theses and Dissertations 4
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Document Description
TitleImmunological studies of psoriatic arthritis
AuthorZipperlen, Katrin.
DescriptionThesis (M.Sc.)--Memorial University of Newfoundland, 2008. Medicine
Date2008
Paginationx, 155 leaves : ill. (some col.)
SubjectB cells; Psoriatic arthritis--Immunological aspects;
Subject.MESHArthritis, Psoriatic--immunology; B-Lymphocytes;
DegreeM.Sc.
Degree GrantorMemorial University of Newfoundland. Faculty of Medicine
DisciplineMedicine
LanguageEng
NotesIncludes bibliographical references (leaves 136-141)
AbstractSince little is known about the contribution of B cells to the pathology of psoriatic arthritis (PsA), this study investigated the possible recruitment of peripheral blood B cells to sites of inflammation by differential expression of chemokine receptors CXCR3, CXCR4, CXCR5, CCR1, CCR2, CCR5 and CCR6. Secondly, we explored the role of B cell activating factor (BAFF) in PsA. The chemokine receptor expression analysis did not reveal any significant differences (p-values >0.05 for all receptors) both at the RNA and the protein level when comparing PsA patients (n = 13) to rheumatoid arthritis (RA) patients (n = 15) and healthy controls (n = 10). Also, there was no significant difference (p = 0.1291) in plasma BAFF levels between PsA (n = 37) or RA patients (n = 24) and healthy controls (n = 35). Our study does not provide supporting evidence of B cell involvement in PsA, however it was limited to the analysis of peripheral blood.
TypeText
Resource TypeElectronic thesis or dissertation
FormatImage/jpeg; Application/pdf
SourcePaper copy kept in the Centre for Newfoundland Studies, Memorial University Libraries
Local Identifiera2544359
RightsThe author retains copyright ownership and moral rights in this thesis. Neither the thesis nor substantial extracts from it may be printed or otherwise reproduced without the author's permission.
CollectionElectronic Theses and Dissertations
Scanning StatusCompleted
PDF File(14.61 MB) -- http://collections.mun.ca/PDFs/theses/Zipperlen_Katrin.pdf
CONTENTdm file name55766.cpd