Memorial University DAI: The utility of HPV DNA testing in triage of low-grade cytological abnormalities

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Title	The utility of HPV DNA testing in triage of low-grade cytological abnormalities
Author	Halfyard, Beth Banks, 1978-
Description	Thesis (M.Sc.)--Memorial University of Newfoundland, 2008. Medicine
Date	2008
Pagination	xi, 86 leaves : ill.
Subject	Cells--Abnormalities; Cervix uteri--Cancer--Testing; Papillomaviruses--Testing;
Subject.MESH	DNA Probes, HPV; Uterine Cervical Neoplasms;
Degree	M.Sc.
Degree Grantor	Memorial University of Newfoundland. Faculty of Medicine
Discipline	Medicine
Language	Eng
Notes	Includes bibliographical references (leaves 74-84)
Abstract	This study evaluated the usefulness of human papillomavirus (HPV) DNA testing and repeat cytology in triage of women referred to colposcopy in St. John's, Newfoundland with atypical squamous cells of undetermined significance (ASCUS) or low-grade squamous intraepithelial lesion (LSIL) cytology. Data were collected on the initial Pap abnormality that prompted referral, HPV test, repeat Pap test, and histology if biopsies were ordered. Of 447 women, 97 with ASCUS and 145 with LSIL had results for all tests. For ASCUS, HPV testing was 100% sensitive for detection of underlying high-grade intraepithelial lesions (HSIL) while reducing referrals to 44.3%. There would have been significant reductions in referrals among women ^30 years of age (74.3%) compared to younger women (27.4%). Nevertheless, in restricting HPV testing to women aged ^30 years, 8/16 women with underlying HSIL would not have been referred to colposcopy. Repeat cytology was less sensitive (75%) for triaging all women. For LSIL, any method would have referred approximately 60% or more if a good sensitivity was achieved in any age group. For ASCUS, HPV triage appears to be more useful than repeat cytology. No useful triage strategy was identified for LSIL.
Type	Text
Resource Type	Electronic thesis or dissertation
Format	Image/jpeg; Application/pdf
Source	Paper copy kept in the Centre for Newfoundland Studies, Memorial University Libraries
Local Identifier	a2543857
Rights	The author retains copyright ownership and moral rights in this thesis. Neither the thesis nor substantial extracts from it may be printed or otherwise reproduced without the author's permission.
Collection	Electronic Theses and Dissertations
Scanning Status	Completed
PDF File	(10.23 MB) -- http://collections.mun.ca/PDFs/theses/Halfyard_BethBanks.pdf
CONTENTdm file name	168936.cpd