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Document Description
TitleThe effects of captopril treatment on hemorrhagic stroke development in stroke-prone spontaneously hypertensive rats
AuthorMacLeod, Andrew B., 1966-
DescriptionThesis (M.Sc.)--Memorial University of Newfoundland, 2001. Medicine
Date2001
Paginationxvii, 195 leaves
SubjectBrain--Hemorrhage--Treatment; Captopril; Hypertension
Subject.MESHStroke--drug therapy; Intracranial Hemorrhage, Hypertensive--drug therapy; Captopril--drug effects; Aldosterone; Angiotensin-Converting Enzyme Inhibitors;
DegreeM.Sc.
Degree GrantorMemorial University of Newfoundland. Faculty of Medicine
DisciplineMedicine
Languageeng
NotesBibliography: leaves 161-195
AbstractWe tested the hypothesis that inhibiting stroke development in Kyoto Wistar stroke-prone rats (SHRsp) with captopril treatment (50 mg/kg) was, in part, mediated by reduced plasma aldosterone levels, independent of an antihypertensive effect. -- Plasma aldosterone levels were measured before and after stroke development in untreated and captopril treated SHRsp. Plasma aldosterone levels suppressed by captopril were re-elevated by aldosterone infusion (16 pg/day) into captopril treated SHRsp. The resulting blood pressure (BP) and stroke development was evaluated. We also examined the BP and antistroke effects of a vasodilating agent, hydralazine (40-100 mg/L), and aldosterone antagonism by spironolactone (20 mg/kg). -- Untreated SHRsp developed hypertension and 100% mortality associated with intracerebral hemorrhage by 14 weeks of age. Captopril treatment from 6 weeks of age did not lower BP but increased survival past 35 weeks of age. Hydralazine lowered BP but only mildly retarded stroke development compared with captopril treated rats. Plasma aldosterone levels increased with age in prestrike SHRsp (0.25 to 3.9 nmol/l) and rose further following stroke (11.4 nmol/l). Captopril treated SHRsp showed suppressed aldosterone values (0.5 nmol/l). Restoring hyperaldosteronemia in captopril treated SHRsp negated captopril's ability to retard stroke development. Spironolactone treatment reduced BP with little effect on stroke development. -- Additional studies assessed the hypothesis that captopril treatment helped preserve contractile function (related to blood flow autoregulation) of isolated middle cerebral arteries (MCA) from SHRsp. This was accomplished by examining lumen diameter changes in response to pressure, protein kinase C activation and potassium induced depolarization in the MCA from untreated and captopril treated, pre and post stroke SHRsp. -- Stroke development was associated with a defect in the ability of the MCA to constrict to elevated transmural pressure (pressure dependent constriction) and phorbol dibutyrate induced protein kinase C activation. Captopril treatment preserved these functions. -- We concluded that elevated plasma aldosterone levels promoted stroke development within captopril treated SHRsp through mechanisms not involving mineralocorticoid receptor stimulation or the exacerbation of hypertension. The antistroke effect of captopril may be partially mediated through plasma aldosterone suppression. We further suggest that the ability of captopril treatment to preserve. MCA pressure dependant constriction may also contribute to the antistroke effects of captopril treatment in SHRsp
TypeText
Resource TypeElectronic thesis or dissertation
FormatImage/jpeg; Application/pdf
SourcePaper copy kept in the Centre for Newfoundland Studies, Memorial University Libraries
Local Identifiera1541762
RightsThe author retains copyright ownership and moral rights in this thesis. Neither the thesis nor substantial extracts from it may be printed or otherwise reproduced without the author's permission.
CollectionElectronic Theses and Dissertations
Scanning StatusCompleted
PDF File(24.97 MB) -- http://collections.mun.ca/PDFs/theses/MacLeod_AndrewG.pdf
CONTENTdm file name170422.cpd