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Memorial University - Electronic Theses and Dissertations 2
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Document Description
TitleTargeted chemotherapy : evaluation of monoclonal anti-CEA antibody drug conjugate efficacy
AuthorCasson, Alan Graham
DescriptionThesis (M.Sc.)--Memorial University of Newfoundland, 1986. Medicine
Date1985
Paginationxvii, 316 leaves : ill. (some col.).
SubjectCEA (Oncology); Monoclonal antibodies; Drugs--Dosage forms
DegreeM.Sc.
Degree GrantorMemorial University of Newfoundland. Faculty of Medicine
DisciplineMedicine
LanguageEng
NotesBibliography: leaves 290-312.
AbstractTargeted chemotherapy, a potentially clinically relevant method of increasing the selective delivery of cytotoxic agents to tumor cell populations has been evaluated. -- The model used in these studies comprised a target, the tumor associated carcinoembryonic antigen, which is expressed by a wide range of human solid tumors, and conjugates of vindesine, a potent vinca alkaloid, covalently linked to a specific monoclonal anti-CEA antibody. -- Characterisation of human tumor cell lines by immunocytochemistry and radiobinding assays established a range of CEA expression enabling selected cell lines to be used for the assessment of conjugate efficacy in vitro, and to be grown as xenografts in nude mice enabling a relevant pre-clinical model to be developed. The effect of conjugate treatment upon the growth of xenografts with a range of CEA expression was then assessed. -- These studies demonstrated the efficacy and selectivity of immunochemotherapy both in vitro and in vivo using this model, confirming theoretical predictions. In addition, prolonged survival of mice treated with conjugate and reduced toxicity of conjugated compared to free drug was demonstrated in one experimental protocol. -- Further investigations and the clinical potential of this approach are discussed.
TypeText
Resource TypeElectronic thesis or dissertation
FormatImage/jpeg; Application/pdf
SourcePaper copy kept in the Centre for Newfoundland Studies, Memorial University Libraries
Local Identifier75370937
RightsThe author retains copyright ownership and moral rights in this thesis. Neither the thesis nor substantial extracts from it may be printed or otherwise reproduced without the author's permission.
CollectionElectronic Theses and Dissertations
Scanning StatusCompleted
PDF File(37.79 MB) -- http://collections.mun.ca/PDFs/theses/Casson_AlanGraham.pdf
CONTENTdm file name66268.cpd