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Document Description
Title
The
correlation
of
medial
composition
of the
abdominal
aorta
and
renal
artery
with
blood
pressure
in the
developing
,
spontaneously-hypertensive
rat
(SHR)
Author
Pang
,
Stephen
Ching-ng
,
1953-
Description
Thesis
(M.Sc.)--Memorial
University
of
Newfoundland
,
1980.
Medicine
Date
1980
Pagination
vii, 121 leaves : ill.
Subject
Abdominal
aorta;
Renal
artery;
Hypertension
Degree
M.Sc.
Degree Grantor
Memorial University of Newfoundland. Faculty of Medicine
Discipline
Medicine
Language
Eng
Notes
Bibliography:
leaves
95-112.
Abstract
The
elevation
of
arterial
blood
pressure
in the
spontaneously
hypertensive
rat
(SHR)
has been
postulated
to be the
result
of
increased
vascular
resistance
and that
such
an
augmentation
of
vascular
resistance
may
be
due
, at
least
in
part
, to
changes
of the
vessel
wall.
The
present
study
is
designed
to
examine
this
hypothesis.
--
Animals
from
each
strain
of
SHR
,
WAR
and
WKY
were
sacrificed
at
2
,
4
,
5
,
6
,
7
,
8
,
12
and
18
weeks
of
age.
Blood
pressures
from
each
group
were
obtained
by
intra-arterial
cannulation.
The
volume
fractions
of
SMC
,
collagen
and
elastin
in the
media
of the
abdominal
aorta
and of the
left
renal
artery
of
2
,
4
,
8
,
12
and
18
weeks
old
animals
were
estimated
by
stereological
analysis
at the
EM
level.
The
estimated
values
of these
components
in the
SHR
were
compared
with those
obtained
from the
WAR
and the
WKY
controls.
--
The
systolic
blood
pressure
in the
SHR
rose
to a
significant
level
from
5
weeks
and
further
increased
to a
hypertensive
level
by
18
weeks
of
age
, as
compared
with the
controls.
As
revealed
by
stereological
analysis
of the
medial
composition
of the
abdominal
aorta
and the
left
renal
artery
of the
SHR
,
no
significant
difference
was
observed
when
comparing
these
parameters
with those of the
controls.
--
The
results
of the
present
study
indicate
that the
medial
components
of the
arteries
studied
were not
significantly
different
among
the
three
strains
of
rat
,
up
to
18
weeks
of
age
,
while
the
systolic
blood
pressure
of the
SHR
was
elevated
significantly
from
5
weeks
of
age.
--
The
elevation
of
arterial
blood
pressure
during
the
development
of the
SHR
therefore
appears
not to be the
result
of
morphological
changes
in the
media
of the
abdominal
aorta
and the
renal
artery.
Type
Text
Resource Type
Electronic
thesis
or
dissertation
Format
Image/jpeg;
Application/pdf
Source
Paper copy kept in the Centre for Newfoundland Studies, Memorial University Libraries
Local Identifier
75072135
Rights
The author retains copyright ownership and moral rights in this thesis. Neither the thesis nor substantial extracts from it may be printed or otherwise reproduced without the author's permission.
Collection
Electronic
Theses
and
Dissertations
Scanning Status
Completed
PDF File
(23.50
MB)
--
http://collections.mun.ca/PDFs/theses/Pang_StephenChing-Ng.pdf
CONTENTdm file name
60436.cpd
