Memorial University DAI: A comparative study on the effects of unilateral intranigral injections of substance P and substance K on circling behavior

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Title	A comparative study on the effects of unilateral intranigral injections of substance P and substance K on circling behavior
Author	Museo, Enrico.
Description	Thesis (M.Sc.) -- Memorial University of Newfoundland, 1986. Psychology
Date	1986
Pagination	v, 62 leaves
Subject	Substance P; Rats--Behavior; Basal ganglia; Tachykinins; Neurochemistry;
Degree	M.Sc.
Degree Grantor	Memorial University of Newfoundland. Dept. of Psychology
Discipline	Psychology
Language	Eng
Notes	Bibliography : leaves 55-62.
Abstract	The effects of unilateral intranigral injections of substance P and the newly discovered tachykinin, substance K, were compared using a rotometer to measure circling behaviour in rats. Various solutions were injected directly into the right substantia nigra pars reticulata (SNR), via chronically implanted guide cannulae. Substance P, substance K, apomorphine and saline were administered sequentially in each rat. This repeated measures design allowed for comparisons to be made with respect to the effects of each solution on circling. Separate groups were formed so that three different concentrations of substance P and substance K could be tested (Groups A, B, C received 8, 12 16 ug /.5 ul, in that order). Groups A, B, and C were pretreated with d-amphetamine, while Group D was not. All groups also received intranigral injections of apomorphine (15 ug /.5 ul) and saline. At a concentration of 12 ug, substance K significantly increased the amount of contralateral circling when compared with the effects of control administrations. These are the first data to indicate that substance K can elicit contraversive circling when administered unilaterally into the SNR. Concentrations of eight and 16 ug of substance K did not significantly increase contralateral circling. None of the three doses of SP elicited significantly more circling than did the saline. Apomorphine was ineffective at increasing circling in three groups, while it significantly increased contraversive circling in one group. In examining the results of the experiment, the effects of each solution are discussed. Explanations that may serve to clarity inconsistencies are proposed, and an effort is also made to reconcile these results with those reported in the relevant literature.
Type	Text
Resource Type	Electronic thesis or dissertation
Format	Image/jpeg; Application/pdf
Source	Paper copy kept in the Centre for Newfoundland Studies, Memorial University Libraries
Local Identifier	75370934
Rights	The author retains copyright ownership and moral rights in this thesis. Neither the thesis nor substantial extracts from it may be printed or otherwise reproduced without the author's permission.
Collection	Electronic Theses and Dissertations
Scanning Status	Completed
PDF File	(9.56 MB) -- http://collections.mun.ca/PDFs/theses/Museo_Enrico.pdf
CONTENTdm file name	304548.cpd